Antidiabetic Chewable Tablet Formulation of Tamarind Leaves (Tamarindus Indica L.) and Ajwa Date Seeds (Phoenix dactylifera L.) Extract Combination

Abstract

Tamarind leaves (Tamarindus indica L.) and ajwa date seeds (Phoenix dactylifera L.) have been widely used to treat diabetes mellitus. Many herbal medicines have been developed into good dosage forms, such as chewable tablet. This study aims to determine the anti-diabetic effect in vivo and determine the good formulation of anti-diabetic chewable tablet from tamarind leaves extract and ajwa date palm seeds extract combination. Tamarind leaves and ajwa date seeds extracts were extracted with 96% ethanol using maceration and soxhletation methods. Then, the compounds contained were screened phytochemical. Anti-diabetic effect of those extracts were treated in alloxan-induced mice (Mus musculus), using a pre and posttest controlled group design method with 2 control and 5 treatment groups. The groups were positive control (0.65 mg/kg glibenclamide), negative control (1% sodium-CMC), group A (280 mg/kg tamarind leaves extracts), group B (392 mg/kg date seeds extracts), group C (TLE:DSE, 75:25), group D (TLE:DSE, 50:50), and group E (TLE:DSE, 25:75). The decrease in glucose levels was observed every 60, 120, and 180 minutes. The highest effect group will be formulated as chewable tablet by wet granulation method. Granules and tablets will be evaluated physically. The highest anti-diabetic effect group was in group C (TLE:DSE 75:25), with aa combined dose of 210 mg/kg and 98 mg/kg. The formula used in this study was considered good, as was the result of granule and tablet evaluation parameters. Tamarind leaves and ajwa date seeds extract combination have an anti-diabetic effect and they can be formulated into anti-diabetic chewable tablet.