In Vitro Antiinflamation and Antioxidant Activity of Etanol Extract of Chromolaena odorata L.

Abstract

Kopasanda (Chromolaena odorata L.) is a species of plant from the Compositae family. Kopasanda can grow in forests and coastal areas, that causing differences in the size of the leaves. This plant is used as a traditional medicine for treating wounds, increasing haemostasis, blood clotting, anti-inflammatory activity, diuretic, and hepatotropic. The leaves contain several active compounds such as flavonoids, alkaloids, saponins, tannins, phytates, cyanogenic glycosides and steroids. The anti-inflammatory test used the protein denaturation method, while the antioxidant test used the Ferric Reducing Antioxidant Power (FRAP) method. The results of the anti-inflammatory test obtained an IC50 value of 299.719 (µg/ml) for forest kopasanda and 284.949 (µg/ml) for coastal kopasanda. While the antioxidant test results obtained antioxidant activity values of 33.673 mgQE/g extract for forest kopasanda and 6.7283 mgQE/g extract for coastal kopasanda. The anti-inflammatory and antioxidant potential of forest kopasanda leaves is better than that of coastal kopasanda.