Formulation and Release Profile of Theophylline Mucoadhesive Granules Using SodiumAlginate, Tragacanth and Combination with Sodium CMC

Abstract

Theophylline is one of methylxanthines which possess bronchodilator properties. Medication with theophylline generally administered every 4-6 hours a day orally. Theophylline is a methylxanthine group which has bronchodilator properties. Medication with theophylline is generally given every 4-6 hours orally. This is not simple to the patient due to the often administration of the drug daily. One strategy to overcome the problem was to make it into mucoadhesive granules . The goal of the research was obtain mucoadhesive granules that possess mucoadhesivity and good release characteristic. Wet granulation method was used to prepare the granules using sodium alginate and tragacanth in concentration of 1%, 5%, 10%, 15% and 20% for each concentration of polymer. Formula that possess fine attachment to the mucous of goat then combined with sodium CMC 1%-10%. Granules evaluation consist of moisture content, wash-off, angle of repose and flowability test, density, porosity and compressibility test, drug content and release test. The release kinetic profile then determined. Three formula were obtained that possesses good adhesivity were obtained formula I,II and III in combination of tragacanth:sodium CMC (15%:8%), sodium alginate:sodium CMC(10%:3%),sodium alginate:sodium CMC (20%:10%) respectively. Results showed that the three formula has good characteristics and release kinetic following Krosmeyer-Peppas n<0.5 which mean that the drug release from the polymer matrices in Fickian diffuse mechanism.